How Did Scientists Learn to Block GM-CSF?
🌏 Available in: English | 한국어 How Did Scientists Learn to Block GM-CSF? The Story Behind Anti-GM-CSF Medicines From Growth Factor to Drug Target When Australian scientist Professor Don Metcalf and his colleagues first discovered granulocyte-macrophage colony-stimulating factor (GM-CSF), together with other colony-stimulating factors such as G-CSF , they initially believed they had identified another growth factor involved in white blood cell production. For years, that assumption seemed correct. GM-CSF was viewed primarily as a molecule that stimulated bone marrow to generate granulocytes and macrophages, helping cancer patients recover after chemotherapy or bone marrow transplantation. World-renowned tenor José Carreras was able to overcome leukemia after participating in a pioneering clinical trial of GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor), highlighting the life-saving potential of this groundbreaking discovery. But science rarely follows a straight li...